Much will undoubtedly rest on the fitness of Mohamed Salah after he was forced off in Liverpool's Champions League final defeat to Real Madrid with a shoulder injury. Since that victory, the closest Uruguay have come is 4th place in both 1970 and 2010.
In the past 10 years, under coach Oscar Tabarez's leadership, the Uruguayan national football team have entered a stable and prosperous period. Since then, they have lost four of their last five friendlies, and were also held to a home draw with Iran.
Uruguay have great pedigree in the World Cup and the two-time winners look to have a very generous route to the second round.
Uruguay face Uzbekistan in a friendly match next Friday before they begin their World Cup campaign against Egypt on June 15. These factors may be to the detriment of the team's focus, and could reduce their chances of making it out of their group.
Argentine manager Hector Cuper who took over the team during 2015 has brought a lot of positive changes to the side.
Martín Fierro: ¿Por qué varios famosos asistieron con algo verde?
Ejemplo de ello fueron las celebraciones de Hollywood y anoche se confirmó en los premios Martín Fierro de la televisión, en nuestro país.
But in 20-year-old Juventus midfielder, Rodrigo Bentancur, they may have just found the answer to their problems.
Suarez's temper. At the 2014 South Africa World Cup, Suarez bit the shoulder of Italian defender Giorgio Chiellini and got a suspension because of it. Without their star player, Uruguay stumbled out of the tournament.
The PSG striker performed amazingly well in the South American qualifiers, scoring 10 goals on the way to taking his team to football's biggest showcase. Despite both the players expected to return to action in the World Cup there has been concern whether they would be at their best fitness. If they can continue this form into the summer there will be few defences that will be able to neutralise this potent attacking force. Cavani is Uruguay's most secure scoring weapon. He graduated from Manchester Metropolitan with a BA in English and Film.
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